脉冲波速度与心力衰竭之间的关联:系统性审查和元分析
Zahra Esmaeili1, Pegah Bahiraie2, Zahra Vaziri3
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Frontiers in cardiovascular medicine
|August 7, 2024
概括
通过脉冲波速度 (PWV) 测量的动脉硬性,在心力衰竭 (HF) 患者中较高. 然而,PWV在患有保留射出分数 (HFpEF) 的HF和减少射出分数 (HFrEF) 的HF患者之间没有显著差异.
科学领域:
- 心血管医学 心血管医学
- 临床生理学 临床生理学
- 生物医学工程 生物医学工程
背景情况:
- 通过脉冲波速度 (PWV) 量化的动脉硬性被公认为心血管风险因素.
- 动脉硬和PWV在心力衰竭与保留射出分数 (HFpEF) 和心力衰竭与减少射出分数 (HFrEF) 的预后意义仍然不完全理解.
研究的目的:
- 在被诊断为心力衰竭 (HF) 的患者中系统地审查和综合PWV和动脉硬的预后值.
- 为了比较HF患者和对照组之间的PWV水平,以及HFpEF和HFrEF子组之间的PWV水平.
主要方法:
- 在Embase,PubMed,Scopus和Web of Science进行了系统的文献搜索,截至2023年8月31日.
- 研究质量使用纽卡斯尔-太华尺度 (NOS) 进行评估.
- 使用元分析和元回归来分析PWV中的标准化平均差异 (SMD),并对相关共变量进行调整.
主要成果:
- 分析包括了24项与64,687名参与者的研究,揭示了与对照组相比,HF患者的PWV显著更高 (SMD1.04,P<0.001).
- 在HFpEF和HFrEF患者之间没有观察到PWV的显著差异 (SMD -0.51,P = 0.057).
- 升高的PWV与患有心血管风险因素的人群中新发性HF风险增加有关.
结论:
- 与普通人群相比,患有HF的患者表现出动脉硬度 (PWV) 的增加.
- 该研究发现HFpEF和HFrEF亚型之间的PWV没有显著差异.
- 需要进一步的研究,以阐明PWV在HF管理中的预后效用.
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