患有间歇性和持续性水性的儿童的病理特征分析,原因是尿道 - 盆腔结口阻塞
Ma Yan1, Zou Jizhen2, Xiao Ping2
1Department of Urology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
Frontiers in pediatrics
|August 7, 2024
概括
与持久病例相比,间歇性水缩症的儿童具有明显的尿道 - 盆腔结合病理. 间歇性水缩显示出更高的Cajal样细胞密度和更好的原与肌肉的比率.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 病理学 病理学 病理学
- 手术科学 手术科学
背景情况:
- 尿道 - 盆腔结口 (UPJ) 的阻塞是儿童水缩的常见原因之一.
- 了解间歇性和持续性UPJ阻塞之间的病理差异对于诊断和治疗至关重要.
- 以前的研究集中在解剖学和功能方面,对UPJ组织本身进行了有限的病理分析.
研究的目的:
- 进行病理分析,比较尿道 - 盆腔结 (UPJ) 组织在间歇性与持久性水性的儿童.
- 为了研究两组之间肌肉含量,原含量和卡哈尔类细胞群的差异.
主要方法:
- 一项比较的病理学研究对46名为UPJ阻塞 (23间歇性,23持续性) 接受皮叶造形手术的儿童进行了比较.
- 从缩小的UPJ段的组织样本被分析到肌肉和原蛋白含量使用马森的三色染色.
- 使用c-kit免疫组织化学量化Cajal样细胞,并计算了原与肌肉的比率 (CMR).
主要成果:
- 间歇性水缩症的儿童与持久性水缩症的儿童相比,表现出明显更高的Cajal样细胞密度 (P < 0.001).
- 间歇性水缩病例的UPJ显示了较低的原蛋白含量和较高的肌肉含量,导致CMR (1.59 ± 0.65) 与持续病例 (3.98 ± 1.19) 相比显著降低 (P < 0.001).
结论:
- 间歇性UPJ阻塞中狭窄的部分的特征是较高的Cajal样细胞密度和更有利的肌肉-原组成.
- 在UPJ组织中这些独特的病理发现可能有助于儿童间歇性水缩与持续性水缩的不同临床表现.
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