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Updated: Jun 17, 2025

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
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SPI1-KLF1/LYL1轴调节了从人类多能干细胞的内皮细胞转化为血型细胞的转变过程中的血统承诺

Kengyuan Qu1,2,3, Shaokang Mo2,3, Junfeng Huang2,3

  • 1Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

iScience
|August 7, 2024
PubMed
概括

转录因子PU.1 (SPI1) 调节人体内皮细胞转化为造血细胞的转变 (EHT),影响造血细胞原生细胞 (HPC) 的生成和血统承诺. SPI1针对KLF1和LYL1,在EHT期间影响髓状和淋巴状分化.

关键词:
生物科学 生物科学细胞生物学;细胞生物学;分子生物学分子生物学分子相互作用分子相互作用.

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