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识别血液培养负性传染性内心炎的危险因素:国际ID-IRI研究

Mine Filiz¹, Hakan Erdem¹, Handan Ankarali²

¹Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Gulhane School of Medicine, Ankara, Turkey.

New microbes and new infections

|August 7, 2024

概括

血液培养阴性内心炎 (BCNE) 是一个难以诊断的挑战. 这项研究确定了增加BCNE风险的患者因素,如年龄和特定的心脏病,有助于早期识别.

科学领域:

传染性疾病传染性疾病
心脏病学心脏病学
临床诊断临床诊断临床诊断

背景情况:

血液培养阴性内心炎 (BCNE) 存在重大诊断挑战.
识别高风险患者队列对于及时诊断和管理BCNE至关重要.

研究的目的:

确定患者的特征和与BCNE增加的可能性相关的并发症.
开发一种预测模型,用于识别患有培养负性内心炎风险较高的患者.

主要方法:

对一系列大型国际成年患者确诊内心炎病例系列的分析.
使用单变量和逻辑回归分析来确定BCNE的预测因素.
通过传染病国际研究计划 (ID-IRI) 在13个国家的41个中心收集了867名患者的数据.

主要成果:

11.65%的患者 (101/867) 患有BCNE.
年龄较大与阴性血液培养的可能性降低有关 (OR 0.975).
风湿性心脏病,大动脉狭窄,额头肌吐和假显著与BCNE的更高几率有关.

结论:

建议在内心炎患者同时存在心脏病的诊断时谨慎行事,特别是年轻人.
该研究提供了一个预测模型 (AUC 0.707),以帮助区分培养阴性和培养阳性内心炎病例.

关键词:

血液培养负性内心炎的血液培养.心脏疾病心脏疾病传染性内心炎是一种感染性内心炎.假体门是一种假体门.风湿性心脏病是一种心脏病.

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