系统性炎症的综合指数作为中风患者死亡率的预测指标
Adalet Göçmen1, Tulin Gesoglu Demir2
1Neurology, Sanliurfa Training and Research Hospital, Sanliurfa, TUR.
Cureus
|August 7, 2024
概括
系统性炎症综合指数 (AISI) 在中风患者中升高,特别是那些患有出血性中风的人. 高于507.45的AISI水平与增加的死亡率相关,这表明它可以作为预后生物标志物使用.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 生物标志物 生物标志物
背景情况:
- 脑卒中是导致死亡和残疾的主要原因,与严重的炎症有关.
- 系统性炎症在中风病原和结果中起着至关重要的作用.
研究的目的:
- 研究系统性炎症综合指数 (AISI) 与中风患者的死亡率之间的关系.
- 确定AISI是否可以作为预测中风预后的可访问生物标志物.
主要方法:
- 对200名中风患者和100名对照进行了回顾性研究.
- 从生物化学和血液计数参数计算各种炎症指数,包括AISI,NLR,PLR,SII和SIRI.
- 统计分析包括相关性和接收器运行特征 (ROC) 曲线分析.
主要成果:
- 与对照组相比,中风患者的炎症指数 (NLR,NHR,PLR,LMR,MLR,SII,SIRI,AISI) 显着更高.
- 出血性中风患者的NLR,PLR,SII,SIRI和AISI比缺血性中风患者更高.
- 虽然在初始分析中没有直接相关性,但ROC分析表明AISI值超过507.45 (p=0.003) 的死亡率增加.
结论:
- 在中风患者中,AISI升高,特别是在出血性中风病例中.
- 超过507.45的AISI值与中风患者的死亡风险增加有关.
- AISI是评估炎症和预测中风预后的有价值和可访问的生物标志物.
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