关于在体外抗菌,抗癌和抗氧化炎症反应的研究 甲醇结核提取物来源于Terminalia chebula
Devadharshini Suresh Kumar1, Arockia Alex1, Brahma Neha1
1Department of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, IND.
来自Terminalia chebula tuber的甲醇提取物显示出显著的抗菌,抗真菌和抗癌性质. 这些天然化合物也表现出强大的抗氧化和抗炎作用,表明治疗潜力.
科学领域:
- 药理学和植物化学
- 自然产品研究自然产品研究
- 癌症生物学 癌症生物学
背景情况:
- 传统医学经常利用植物衍生化合物用于治疗目的.
- 切布拉 (Terminalia chebula) 是一种具有药用历史的植物.
- 研究传统疗法的科学基础对于现代药物发现至关重要.
研究的目的:
- 评估Terminalia chebula tuber提取物的抗菌,抗真菌和植物化学特征. 为了评估Terminalia chebula tuber提取物的抗菌,抗真菌和植物化学特征.
- 对口腔癌细胞系进行体外抗癌活性评估.
- 为了确定提取物的抗氧化和抗炎潜力.
主要方法:
- 制备了Terminalia chebula的甲醇结核提取物.
- 抗菌和抗真菌活性被评估使用阿加井扩散.
- 用标准技术分析了植物化学成分.
- 在实验室中,使用MTT测定对口腔癌细胞系 (KB-1) 的抗癌作用进行了评估.
- 通过特定的测定来确定抗氧化和抗炎活性.
主要成果:
- 特米纳利亚切布拉提取物对KB-1口腔癌细胞系表现出显著的细胞毒性作用,降低了细胞活力.
- 在30μg/mL时,观察到表明细胞损伤的形态变化.
- 这些提取物表现出强烈的抗氧化 (85.3%的吸收) 和抗炎 (76.0%的吸收) 活性.
- 发现了显著的抗菌活性,特别是在较高度下对抗Streptococcus mutans和Candida albicans.
结论:
- 甲醇提取物的Terminalia chebula 管拥有有前途的抗菌,抗真菌,抗氧化,抗炎和细胞毒性质.
- 提取物在30μg/mL时诱导了口腔癌细胞的亡,表明了治疗潜力.
- 需要进一步的研究来阐明活性化合物及其作用机制,以实现潜在的商业发展.
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