评估尼古丁替代疗法在重症吸烟者的有效性:随机对照试验的元分析
Ohoud Aljuhani1, Khalid Al Sulaiman2,3,4,5,6, Hadeel Alkofide7,8
1Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Tobacco induced diseases
|August 7, 2024
概括
尼古丁替代疗法 (NRT) 显著缩短了重症监护室 (ICU) 住院时间. 然而,NRT在机械通风,血管压缩剂使用或妄想持续时间方面没有显著差异.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 尼古丁替代疗法 (NRT) 在重症患者中的有效性是有争议的,因为研究结果相互矛盾.
- 吸烟者在重症监护室 (ICU) 中使用NRT来治疗戒烟和动.
- 现有的关于NRT在这个人群中的安全性和有效性的数据不一致.
研究的目的:
- 评估NRT在重症患者吸烟者的有效性.
- 评估NRT对ICU停留时间 (LOS) 的影响.
- 分析NRT对机械通风,妄和血管压缩器持续时间的影响.
主要方法:
- 随机对照试验的系统审查和元分析.
- 在MEDLINE和Embase数据库中搜索到2023年2月13日.
- 包括比较ICU吸烟者的NRT与无NRT的研究;主要结局是ICU LOS.
主要成果:
- 分析了三项涉及139名患者的研究 (67名NRT,72名对照).
- NRT显著减少了ICU停留时间 (LOS) (MD=-3.06天,p=0.0).
- 对于机械通风,妄或血管压力器持续时间,没有发现显著差异.
结论:
- 在重症吸烟者中使用NRT与显著缩短ICU LOS有关.
- NRT并没有显著影响机械通风的持续时间,妄或血管压缩剂的使用.
- 进一步的研究可能会澄清NRT在治疗重病吸烟者的作用.
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