变性人和性别非二元个体的阴道微生物组
Gabrielle Winston McPherson1, Zil Goldstein2, Stephen J Salipante1
1Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Transgender health
|August 7, 2024
概括
变性人和非二元性别个体具有独特的阴道微生物组,与 cisgender 个体相比,它们具有更高的多样性和不同的细菌物种. 新阴道表现出多样性增加和独特的微生物组成,而不是由Lactobacillus主导.
科学领域:
- 微生物组研究的研究.
- 泌尿生殖系统医学
- 跨性别者健康问题
背景情况:
- 阴道微生物群在生殖健康中起着至关重要的作用.
- 变性人和性别非二元 (TGNB) 个人可能会接受性别确认手术,包括新阴道的创造.
- 关于新阴道在健康和疾病中的微生物组成的了解有限.
研究的目的:
- 描述跨性别和性别非二元 (TGNB) 个体的阴道微生物组.
- 将TGNB个体的阴道微生物组与 cisgender个体进行比较.
- 为了确定新阴道与出生阴道的微生物差异.
主要方法:
- 试点研究涉及15名TGNB和8名 cisgender参与者.
- 自我收集的阴道抽样.
- 下一代16S核糖体RNA测序用于细菌社区概况.
主要成果:
- 与 cisgender 参与者相比,TGNB 参与者表现出明显更高的个体内 (alpha) 多样性 (p=0.0003).
- 在TGNB参与者的样本中发现了肠道和皮肤共生的微生物物种.
- 在 cisgender 个体中占主导地位的 Lactobacillus 种,在 TGNB 个体中存在较低的丰度 (≤3%).
结论:
- 与出生性阴道相比,新阴道具有更多的α多样性和独特的微生物组成.
- 新阴道中没有乳酸菌占主导地位,而是各种微生物物种的宿主.
- 了解新阴道微生物组对于区分健康和疾病状态至关重要.
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