生物医学SERS - 目前的状态和未来的趋势
Dana Cialla-May1,2, Alois Bonifacio3, Thomas Bocklitz1,2,4
1Leibniz Institute of Photonic Technology, Member of Leibniz Health Technologies, Member of the Leibniz Centre for Photonics in Infection Research (LPI), Albert-Einstein-Straße 9, 07745 Jena, Germany. dana.cialla-may@leibniz-ipht.de.
Chemical Society reviews
|August 7, 2024
概括
表面增强拉曼光谱 (SERS) 为生物医学应用提供了一个敏感和特定的工具. 本综述涵盖了SERS样品的准备,检测方法和现场诊断的活性表面.
科学领域:
- 生物医学科学 生物医学科学
- 分析化学 分析化学
- 频谱学是一种光谱学.
背景情况:
- 表面增强拉曼光谱 (SERS) 是一种高度敏感和特定的分析技术.
- 便携式拉曼系统和量身定制的样品制备使得护理点测试 (POCT) 成为可能.
- 稳定的SERS活性表面可用于复杂的生物矩阵,如体液和细胞.
研究的目的:
- 对生物医学应用中样本采集和预处理的当前SERS协议进行审查.
- 总结SERS检测方案,包括直接,间接,有针对性和非有针对性的方法.
- 突出SERS在疾病诊断和药物监测方面的最新进展.
主要方法:
- 关于SERS样品处理和准备技术的文献综述.
- 对不同SERS检测策略和主动传感表面的分析.
- 在传染病,癌症诊断和治疗药物监测中编制SERS应用程序.
主要成果:
- 通过适当的样本准备和传感表面,SERS是生物医学中POCT的一个可行的工具.
- 不同的SERS检测方案和基板适用于不同的生物样品.
- 在诊断疾病和监测药物水平方面,SERS显示出了显著的进展.
结论:
- 本综述为选择最佳SERS协议,基板和特定生物医学应用的检测策略提供了一份指南.
- 在临床诊断和个性化医疗中,SERS技术正在得到广泛应用.
- 了解SERS方法对于其在医疗保健机构的有效实施至关重要.
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