一种前脊椎动物内皮起源的产生色素的神经内分泌细胞,产生色素
Jenaid M Rees1, Katie Kirk1, Giacomo Gattoni1,2
1Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
Development (Cambridge, England)
|August 7, 2024
概括
脊椎动物产素的细胞 (C细胞) 起源于内皮,而不是神经. 这种内皮起源在脊椎动物中得到保护,并且早于它们的进化.
科学领域:
- 发展生物学 发展生物学
- 内分泌学 在内分泌学.
- 进化生物学 进化生物学
背景情况:
- 脊椎动物产出素的细胞 (C细胞) 是神经内分泌细胞,对平衡至关重要.
- 人们一直在争论C细胞的胚胎起源,并提出从内皮和神经两者的衍生.
- 了解C细胞的起源是理解脊椎动物内分泌发育和进化的关键.
研究的目的:
- 解决脊椎动物产细胞 (C细胞) 的祖先胚胎起源.
- 研究跨越多种脊椎动物血统的C细胞起源的进化保存.
- 在无脊椎动物中识别潜在的C细胞前体.
主要方法:
- 在多个脊椎动物模型系统中比较细胞系的追踪.
- 对小,斑马鱼和小滑板的胚胎发育进行分析.
- 在无脊椎带动物 (Ciona intestinalis,Branchiostoma lanceolatum) 中检查上皮质.
主要成果:
- 与之前的报道相反,小的C细胞来自内皮.
- 神经细胞有助于结缔组织周围的C细胞在鸟类的终端支骨腺.
- C细胞的内皮来源在斑马鱼和小滑板中得到保护.
- 假设的C细胞同类在无脊椎动物带动物的内皮中被发现.
结论:
- 来自内皮的产细胞 (C细胞) 的胚胎起源在脊椎动物的整个进化过程中都保持着.
- 这种内皮血统早于脊椎动物的出现,可以追溯到带体干.
- 这些发现挑战了关于鸟类C细胞起源的先前假设,并突出了保存的发育途径.
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