儿童和青少年体重不足和非典型的精神性厌食症的血液参数
I Flamarique1,2,3, M Pineda4, E Tasa-Vinyals1,2,5
1Department of Child and Adolescent Psychiatry and Psychology, 2021SGR01319, Institut Clínic de Neurociències, Hospital Clínic de Barcelona, Barcelona, Spain.
The International journal of eating disorders
|August 7, 2024
概括
体重不足的神经性厌食症 (AN) 和非典型AN的儿童和青少年具有相似的生化和血液学异常. 然而,体重不足的AN组表现出更高的胆固醇和氨酸转移酶的高频率,表明某些医学并发症的明显风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 儿童和青少年精神病学 儿童和青少年精神病学
- 临床生物化学 临床生物化学
背景情况:
- 神经性厌食症 (AN) 是一种严重的饮食障碍,具有重大医学并发症.
- 体重不足的AN和非典型的AN是不同的诊断类别,但它们的医学后果需要彻底调查.
- 了解生物化学,血液学和内分泌学概况对于在儿科患者中管理这些疾病至关重要.
研究的目的:
- 识别和比较诊断为体重不足的儿童和青少年的生物化学,血液学和内分泌学异常,与非典型的AN相比.
- 阐明与这两种AN亚型相关的医疗风险的潜在差异.
主要方法:
- 根据第五个BMI百分位数,回顾入院青少年的医疗记录.
- 包括两个组:体重不足的AN (n=520) 和非典型的AN (n=255).
- 生物化学,血液学和内分泌学参数的分析.
主要成果:
- 在整个样本中,低前专辑蛋白 (35%),中性质减退 (39%) 和内分泌异常 (50%) 是普遍存在的.
- 与非典型的AN组相比,体重不足的AN组显示胆固醇和氨酸转移酶的升高率显著更高.
- 体重不足的AN还与胰岛素样生长因子-1 (IGF-1),T3,黄素激素 (LH),毛囊刺激激素 (FSH) 和17b-雌激素水平显著降低有关.
结论:
- 体重不足的AN和非典型的AN都存在,在血液参数中具有共同的异常.
- 特定的异常,如胆固醇和肝酶升高,在体重不足的AN中更为频繁.
- 这些发现表明,非典型的AN和体重不足的AN可能会给某些医学并发症带来类似的风险,尽管存在一些差异.
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