免疫检查点抑制剂和轨道;两例反应性乳腺炎病例
Matthew Fenech1, Ayodeji Ajanaku1, James Hsuan1
1Department of Ophthalmology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Orbit (Amsterdam, Netherlands)
|August 7, 2024
概括
免疫检查点抑制剂 (ICPi) 可能会导致罕见的副作用,如乳腺炎. 这项研究详细介绍了两例双边反应性乳腺炎的病例,这些病例发生在接受ICPI治疗的患者中.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
背景情况:
- 免疫检查点调节免疫反应,防止组织损伤.
- 免疫检查点抑制剂 (ICPi),如抗CTLA-4,抗PD-1和PD-L1疗法,可以激活抗瘤活性.
- 目前的ICPI疗法,包括ipilimumab,nivolumab和pembrolizumab,显示出有希望但副作用限制.
研究的目的:
- 报告ICPI治疗之前未描述的副作用:双边反应性乳腺炎.
- 强调识别免疫治疗的眼部表现的重要性.
主要方法:
- 两名接受ICPI治疗的女性患者的病例报告.
- 双边反应性乳腺炎的临床表现和诊断.
主要成果:
- 这两名患者在ICPI治疗后出现了双边反应性乳腺炎.
- 这种特定的眼部副作用在医学文献中以前没有被记录.
结论:
- 双边反应性乳腺炎是一种与免疫检查点抑制剂治疗相关的潜在,以前未报告的不良事件.
- 需要进一步的研究来了解ICPI诱导的眼部副作用的机制和发病率.
关键词:
免疫检查点抑制剂 免疫检查点抑制剂在IRAEs的IRAEs.这里是 ipilimumab 的所在地.眼腺活检 眼腺活检这就是尼沃卢马布 (nivolumab).这就是Pembrolizumab.反应性乳腺炎的发生.更多相关视频
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