结肠直肠癌复发预测使用无组织表观基因组最小残留疾病试验
Yoshiaki Nakamura1,2, Yuichiro Tsukada3, Nobuhisa Matsuhashi4,5
1Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.
概括
一种新的无组织测定方法使用结直肠癌患者的循环瘤DNA (ctDNA) 准确检测到最小的残留疾病,预测早期复发. 这种非侵入性方法提供了快速的结果,以指导临床决策.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 癌症基因组学 癌症基因组学
背景情况:
- 循环瘤DNA (ctDNA) 的治疗后检测是癌症复发的强有力的预测因素.
- 目前的最小/分子残留疾病测定通常需要先前进行组织测试,导致延迟和无价值的患者.
研究的目的:
- 评估一种用于检测ctDNA的新型无组织测定方法 (守护揭示).
- 评估测试在切除结直肠癌患者中识别最小/分子残留疾病的能力.
主要方法:
- 生物信息学评估>20,000个表观基因组区域用于ctDNA检测.
- 分析了从342名切除结直肠癌患者的1,977个纵向收集的术后血样本.
主要成果:
- 实现了微小/分子残留疾病的敏感和特定检测,中位数预先检测时间为5.3个月.
- 在II阶段+结肠癌中,经证实81%的纵向灵敏度,随着连续测量而增加.
- 在治疗后的样本中报告了高特异性 (98.2%),敏感度因复发部位而异.
结论:
- 该ctDNA测定显示了治疗II+期结直肠癌的潜在临床实用性.
- 非侵入性,易于使用的方法允许快速评估以告知临床决策.
- 这种方法可以通过早期检测复发来改善患者管理.
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