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Updated: Jun 17, 2025

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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Published on: March 28, 2017

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硫转移酶介导的II期药物代谢预测基质和部位使用基于可访问性和反应性的算法

Shivam Kumar Vyas1, Avik Das2,3, Upadhyayula Suryanarayana Murty1

  • 1Department of Medicinal Chemistry, Department of Pharmaceuticals, Ministry of Chemicals & Fertilizers, Govt. of India, Sila Katamur (Halugurisuk), P.O.: Changsari, Dist: Kamrup, Pin, National Institute of Pharmaceutical Education and Research, Guwahati, (NIPER Guwahati), Guwahati, Assam, 781101, India.

Molecular informatics
|August 7, 2024
PubMed
概括

这项研究引入了新的模型,用于通过硫转移酶 (SULT) 预测药物代谢,提高了识别药物相互作用和潜在失效的准确性. 开发的SOS预测器为药物发现提供了宝贵的见解. 关键词:药物代谢,硫转移酶,SULT,药物相互作用,SOS预测器.

关键词:
第二阶段新陈代谢.可访问性可访问性药物代谢 药物代谢反应性反应性是指反应性.硫化位的位置硫转移酶是一种硫转移酶.

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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling09:33

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