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Updated: Jun 17, 2025

Investigating the Phagocytosis of Leishmania using Confocal Microscopy
08:41

Investigating the Phagocytosis of Leishmania using Confocal Microscopy

Published on: July 29, 2021

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确定Rab2蛋白作为Centrin1的关键交互因子,对Leishmania捐赠者的生长至关重要

Roshanara1, Rati Tandon1, Mirza Sarwar Baig2

  • 1Department of Molecular Medicine, Jamia Hamdard, New Delhi 110062, India.

ACS infectious diseases
|August 7, 2024
PubMed
概括

删除Leishmania donovani生长基因LdCen1的影响寄生虫阶段. 一种新型蛋白质LdRab2补偿了细胞外前子的生长,与LdCen1和其他中心蛋白相互作用.

关键词:
莱什曼尼亚的捐赠人Rab2 蛋白质是 Rab2 的一种蛋白质.中心蛋白质是中心蛋白质.活体减弱疫苗的疫苗.促成激烈的运动.蛋白质与蛋白质的相互作用

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Rab Proteins01:14

Rab Proteins

Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
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