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Updated: Jun 17, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

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皮肤模样形和Vδ2 γδT细胞扩张在STK4缺乏症中

Wenjing Ying1,2, Xin Long1,3, Travis Vandergriff4

  • 1Division of Digestive and Liver Diseases, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Suite J5.136, Dallas, TX, 75390-9151, USA.

Journal of clinical immunology
|August 7, 2024
PubMed
概括

免疫的先天性错误 (IEI) 可以导致各种感染. 这项研究发现,STK4缺乏导致马-三角形T细胞扩张,可能会补偿受损的CD4+T细胞对抗病毒感染.

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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