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Updated: Jun 17, 2025

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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向BRD4减弱RANKL诱导的骨质细胞激活和骨质侵蚀在类风湿性关节炎

Changyao Wang1, Han Zhang1, Xiangyu Wang1

  • 1Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China.

Molecular and cellular biochemistry
|August 7, 2024
PubMed
概括

在类风湿性关节炎 (RA) 模型中,用JQ1抑制odomain 4 (BRD4) 有效地降低了炎症和骨破坏. 向BRD4为RA诱导的骨损失提供了一个潜在的治疗策略.

关键词:
这就是BRD4D.骨的破坏 骨的破坏JQ1 一个问题在RANKL/RANK信号通道中.类风湿性关节炎 类风湿性关节炎 类风湿性关节炎

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