阴道状况调节大弹性动脉硬度在健康的中年和老年男性
Lyndsey E DuBose1, Matthew C Babcock1, Wendy M Kohrt1,2
1Division of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, 12631 East 17th Ave., Mail Stop B179, Aurora, CO, 80045, USA.
GeroScience
|August 7, 2024
概括
阴性腺症可能会加速与年龄相关的动脉硬化中年/老年男性,独立于心血管疾病的风险因素. 这种硬化与对维生素C敏感的氧化应激增加无关.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 血管生物学 血管生物学
背景情况:
- 阴性腺是男性心血管疾病 (CVD) 的风险因素,部分原因是氧化应激.
- 大型动脉硬和中央血液动力学是独立的心血管疾病风险因素.
- 人们还没有完全理解阴性腺症,动脉硬,血液动力学和氧化应激之间的关系.
研究的目的:
- 为了调查如果大动脉硬度和中央血液动力学在低体男性中升高,独立于传统的心血管疾病风险因素.
- 为了确定这些血管变化是否与增加的氧化应激有关.
主要方法:
- 动脉硬度 (动脉β-硬度) 和中央血液动力学在年轻和中年/老年男性 (MA/O) 评估,这些男性的丸激素水平正常或低.
- 参与者接受了盐水或维生素C的输液,以评估氧化应激下血管功能.
- 使用了脉冲波分析 (SphygmoCor XCEL) 和超声波.
主要成果:
- 在低丸激素的MA/O男性中,冠状动脉硬度高于正常丸激素的男性,而不依赖年龄.
- 中心脉动性血液动力学在各组之间没有显著差异.
- 维生素C降低了正常丸激素的男性的大动脉反射幅度,但没有降低丸激素的男性.
结论:
- 阴性腺症可能会加速与年龄相关的大动脉硬化在MA/O男性,独立于传统的心血管疾病风险因素.
- 在男性中观察到的动脉硬化与急性维生素C给药敏感的活性氧物种增加没有直接关系.
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