对纤维素素作为缺血风险因素的新兴兴趣
Udaya S Tantry1, Kevin P Bliden1, William W Ashley2
1Sinai Center for Thrombosis Research and Drug Development, Sinai Hospital of Baltimore and Lifebridge Health System, Baltimore, MD, 21209, USA.
Journal of thrombosis and thrombolysis
|August 7, 2024
概括
纤维素水平在心血管疾病 (CVD) 和COVID-19患者中显著影响血小板纤维素凝块强度 (P-FCS). 更高的纤维素素与凝块强度的增加有关,这表明它在动脉血栓形成中起着关键作用.
科学领域:
- 心血管医学 心血管医学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 血小板纤维素凝块的形成在动脉血栓形成中至关重要.
- 在心血管疾病和COVID-19中,凝块强度和纤维素素之间的联系还没有得到充分研究.
研究的目的:
- 调查纤维素素对血栓诱导的血小板纤维素凝块强度 (P-FCS) 的贡献.
- 为了比较健康受试者,COVID-19患者和心血管疾病患者的P-FCS和纤维素原水平.
主要方法:
- 使用酸盐盒子使用的血造影 (TEG 6s).
- 分析了P-FCS,纤维素凝块强度 (F-CS) 和纤维素原水平 (FLEV).
- 包括健康受试者 (n=157),COVID-19患者 (n=116) 和心血管疾病患者 (n=93).
主要成果:
- 与健康受试者相比,心血管疾病和COVID-19患者的P-FCS,F-CS和FLEV都增加了 (p<0.05).
- COVID-19患者表现出最高的P-FCS,F-CS和FLEV.
- P-FCS与F-CS和FLEV有很强的相关性 (R2=0.67,p<0.001).
结论:
- 纤维素水平显著影响了血小板纤维素凝块的粘弹性强度.
- 纤维素素可能是动脉血栓形成的关键因素,可能与高血小板反应性一样重要.
- 对于个性化抗血栓治疗,需要对纤维素原的作用进行进一步的研究.
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