在健康的老年男性和女性中延迟和减少食后乳酸穿
Jose A Arevalo1, Robert G Leija1, Adam D Osmond1
1Exercise Physiology Laboratory, Department of Integrative Biology, University of California, Berkeley, United States.
American journal of physiology. Endocrinology and metabolism
|August 7, 2024
概括
饭后的乳酸转移对于能量代谢至关重要,与年轻人相比,在老年人中延迟和减少. 这种与年龄相关的衰退影响了葡萄糖挑战后的肠道和全身乳酸盐过程.
科学领域:
- 代谢生理学 代谢生理学
- 衰老的研究研究.
- 营养科学 营养科学
背景情况:
- 乳酸盐是糖解的关键产物,在能量代谢中起着至关重要的作用.
- 虽然乳酸流量在年轻和运动的人群中得到了很好的研究,但其在老龄化人口中的动态仍然不清楚.
- 了解乳酸代谢与年龄相关的变化对于老年人代谢健康至关重要.
研究的目的:
- 调查年龄对食后乳酸转移 (PLS) 的影响.
- 为了测试PLS在老年人中减弱的假设.
- 为了比较年轻和老年健康个体之间的乳酸的出现,消失和氧化率.
主要方法:
- 使用稳定同位素标记物 ([3-13C]乳酸盐和[6,6-2H]葡萄糖) 进行精确的代谢跟踪.
- 用口服葡萄糖耐受性测试 (OGTT) 来模拟饮食反应.
- 采用动脉化血液采样来确定食后乳酸的出现率 (Ra),消失率 (Rd) 和氧化率 (Rox).
主要成果:
- 与年轻参与者相比,老年人表现出延迟和减少的乳酸Ra和度峰值.
- 在整个试验中,乳酸氧化 (Rox) 在年轻人中始终较高.
- 观察到肠道和全身PLS阶段,全身乳酸Ra与葡萄糖Rd有很强的相关性.
结论:
- 餐后乳酸转移,包括肠道和全身阶段,在健康的老年人中明显延迟和减少.
- 乳酸代谢与年龄相关的障碍可能会对老年人群的能量恒温和代谢灵活性产生影响.
- 需要进一步的研究来探索这些与年龄相关的代谢变化的功能后果.
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