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慢性病老年人的蛋白质摄入量和死亡率
Adrián Carballo-Casla1,2, Carla Maria Avesani3, Giorgi Beridze1
1Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
JAMA network open
|August 7, 2024
概括
动物和植物来源的较高蛋白质摄入量与慢性病 (CKD) 的老年人死亡率降低有关. 这些发现表明,蛋白质的益处可能超过轻度至中度CKD患者的风险.
科学领域:
- 老年学是一门学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 饮食中的蛋白质摄入对于老年人来说至关重要,但其在慢性病 (CKD) 中的作用仍在争论中.
- 高蛋白饮食可能会导致功能下降的风险,但潜在的生存益处尚不清楚.
研究的目的:
- 调查总体,动物和植物蛋白摄入量与老年轻度或中度CKD所有原因死亡率之间的关联.
- 将这些关联与在没有CKD的个体中观察到的关联进行比较.
主要方法:
- 分析了来自三个大队伍的数据,包括60岁以上的社区成年人.
- 通过验证的问卷评估饮食中的蛋白质摄入量;死亡率追踪了10年.
- 患有晚期CKD (4-5期) 或接受替代疗法的参与者被排除在外.
主要成果:
- 在患有CKD的参与者中,较高的总蛋白质摄入与死亡率降低相关 (例如,HR为1.40的0.73与0.80g/kg/d相比).
- 动物和植物蛋白摄入量都显示出与死亡率的相似反向关联.
- 蛋白质摄入与死亡的保护性关联在没有CKD的个体中比CKD的个体更强.
结论:
- 增加总,动物和植物蛋白的摄入量与老年轻度至中度CKD的死亡率降低有关.
- 在这个人群中,蛋白质消费的好处似乎超过了潜在的风险.
- 研究结果强调了足够的蛋白质摄入对于患有CKD的老年人生存的重要性.
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