美国男性和女性的林格南摄入量和2型糖尿病发病率
Siyue Wang1,2, Yang Hu1, Binkai Liu1
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
JAMA network open
|August 7, 2024
概括
植物性食品中发现的类化合物的摄入量较高,与患2型糖尿病 (T2D) 的风险降低有关. 这种保护作用在肥胖和绝经前妇女中尤为明显.
科学领域:
- 营养科学 营养科学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 林是一种常见于西方饮食中的植物性雌激素.
- 红素的消费可能会影响患2型糖尿病 (T2D) 的风险.
研究的目的:
- 为了前性地研究干素摄入量与2型糖尿病 (T2D) 发生率之间的关联.
主要方法:
- 一项大型基于人口的队列研究,涉及来自护士健康研究 (NHS),NHSII和卫生专业人员随访研究 (HPFS) 的美国男性和女性.
- 通过经过验证的食物频率问卷和7天饮食记录 (7DDRs) 评估饮食里格南摄入量.
- 使用美国糖尿病协会的标准确定了事件T2D病例,并使用了Cox比例危险模型进行分析.
主要成果:
- 较高的干素摄入量与T2D发病率相反相关,拉里基雷辛醇是显著的例外.
- 摄入secoisolariciresinol显示,在肥胖和绝经前妇女中,与T2D风险有显著的反向关联.
- 通过7DDR评估的食干素摄入量与改善的血糖控制 (降低HbA1c),降低C反应蛋白水平和更好的脂质配置文件相关联.
结论:
- 长期的干素消费与2型糖尿病 (T2D) 的风险降低有关.
- 在肥胖和绝经前妇女中,对T2D的保护性关联性较为明显.
- 素可能在代谢健康中发挥有益作用,影响T2D风险和相关生物标志物.
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