关于肥胖流行病的微观进化假设
Joseph Fraiman1, Scott Baver2, Maciej Henneberg3,4,5
1Department of Graduate Education, Geisinger Commonwealth School of Medicine, Scranton, PA, United States of America.
PloS one
|August 7, 2024
概括
现代产科降低了分娩死亡率,解除了对肥胖的关键进化压力. 人类基因库中的这种微观进化转变可能解释了全球肥胖流行病.
科学领域:
- 人类进化人类的进化.
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 全球肥胖流行病是人类显著的表型变化.
- 肥胖是高度遗传的,但快速的基因库变化通常不被认为是其原因.
- 现代产科大大改变了与肥胖相关的进化压力.
研究的目的:
- 为了测试肥胖流行病的微观进化假设.
- 调查降低婴儿死亡率与肥胖率上升之间的联系.
- 为了确定人类基因库的变化,受产科的影响,是否有助于肥胖流行.
主要方法:
- 对大约190个国家的数据进行回归分析.
- 研究了1990年终身孕产妇死亡率 (LMDR) 和当前肥胖率之间的关联.
- 多变量回归和部分相关性分析控制GDP,卡路里摄入量和身体不活动.
主要成果:
- LMDR与国家肥胖率的相关性比GDP,卡路里摄入量或身体不活动更强.
- LMDR解释了大约11%的国家之间的肥胖率的变化.
- 在高LMDR的国家,这个指标解释了33%的肥胖差异,独立于其他因素.
结论:
- 微观进化假设为全球肥胖流行病提供了一个节的解释.
- 由于现代产科的减少孕产妇死亡率,可能会消除对肥胖的负面选择压力.
- 人类基因库中的进化变化可能是当前肥胖危机的重要驱动因素.
相关概念视频
Genetic Drift
39.6K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
39.6K
Evolutionary Psychology
257
Evolutionary psychology explores the origins of human behavior and mental processes by framing them within the context of natural selection, a theory famously propounded by Charles Darwin. This field asserts that many behaviors common across human societies — ranging from instinctive fear reactions to complex social interactions — arose as evolutionary adaptations. These adaptations enhanced the survival and reproductive success of our ancestors, thereby becoming embedded in the...
257
Obesity
418
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
418
The Evidence for Evolution
42.6K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
42.6K
Genome Size and the Evolution of New Genes
7.9K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
7.9K
Genetics of Speciation
19.2K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
19.2K


