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Updated: Jun 17, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

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快速和可扩展的集体学习方法,用于多元基因风险预测

Tony Chen1, Haoyu Zhang2, Rahul Mazumder3

  • 1Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02215.

Proceedings of the National Academy of Sciences of the United States of America
|August 7, 2024
PubMed
概括

一种使用总结级数据 (ALL-Sum) 的新方法,聚合L0Learn,显著改善了多基因风险评分 (PRS) 的计算. 它为个性化医学应用提供了更高的准确性,更快的计算速度和更低的内存使用量.

关键词:
L0学习学习.组合学习组合学习受到惩罚的回归回归.多基因风险得分的多基因风险得分.

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