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Updated: Jun 17, 2025

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
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Wapl与凝聚素复合体相互作用的分子机制和功能意义

Xueying Yuan1, Lu Yan1, Qinfu Chen1

  • 1Department of Gynecologic Oncology of Women's Hospital, School of Medicine and MOE Laboratory of Biosystems Homeostasis & Protection, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Proceedings of the National Academy of Sciences of the United States of America
|August 7, 2024
PubMed
概括

凝聚素释放因子Wapl使用两个模块来结合Scc1-SA2接口,释放凝聚素以进行适当的染色体分离. 两个模块中的突变阻止了Wapl结合,并导致细胞分裂中的错误.

关键词:
凝聚力 在凝聚力中这是 Wapl Wapl.染色体分离是染色体的分离.发生线粒分裂 (mitosis).姐妹染色体凝聚力的一致性

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