评估临床医生报告的结局措施,以治疗白发症:一个系统的范围审查审查
Emadodin Darchini-Maragheh1,2, Anthony Moussa2, Huw Rees2
1Department of Medicine, The University of Melbourne, VIC, Australia.
Clinical and experimental dermatology
|August 7, 2024
概括
临床医生报告的结局指标 (ClinROMs) 对于白发病 (AA) 缺乏共识,阻碍了全面的疾病评估. 一项审查确定了16个ClinROM,但实际限制需要一个新的,复合的AA严重性评分系统.
科学领域:
- 皮肤病学和三叶病学
- 临床试验方法论 临床试验方法论
- 结果测量 结果测量
背景情况:
- 临床医生报告的结果测量 (ClinROMs) 对于在临床实践和研究中评估白发病 (AA) 严重程度至关重要.
- 目前对AA的ClinROM显示出关于其适用于综合性疾病评估的适当性存在重大分歧.
研究的目的:
- 系统地识别和评估现有的AA的ClinROM.
- 分析这些评估工具的实际优点和弱点.
- 概述未来的研究方向,以改善AA严重性测量.
主要方法:
- 使用PubMed (MEDLINE) 和Embase (Ovid) 数据库进行了系统的文献搜索.
- 包括的文章是在2000年以后出版的,用英语,客观地测量了AA严重程度.
- 排除标准侧重于仅基于患者报告的结果排除工具.
主要成果:
- 搜索在各种领域产生了16个不同的ClinROMs:头皮脱发 (5),基于三角镜的疾病活动 (3),非头皮区域 (6),和头皮/非头皮综合评估 (2).
- 确定的特定工具包括SALT,SALT II,ALODEX,pSALT,AA-IGA,AAPI,AAPS,可编织性头发得分,BETA,BELA,ALBAS,ClinRO措施,AASI和AASc. 这些工具包括:
- 详细介绍了每个确定工具的优势和局限性.
结论:
- 目前对AA的ClinROM面临实际局限性,这阻碍了广泛的临床采用.
- 需要一个全面的临床严重性评分系统,包括所有关键的AA标识符,超越头皮干扰.
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