长期痴呆症在帕金森病中的风险
Julia Gallagher1, Caroline Gochanour1, Chelsea Caspell-Garcia1
1From the Departments of Neurology (J.G., A.S.C.-P., N.D., J.M., A.D.S., A.W.W., D.W.) and Psychiatry (E.M., D.W.), and Biostatistics and Epidemiology (S.X.X.), University of Pennsylvania, Philadelphia; Department of Biostatistics (C.G., C.C.-G., C.S.C.), University of Iowa; Department of Psychiatry (R.D.D.), Rutgers University, Newark, NJ; Department of Old Age Psychiatry (D.A.), Kings College London, UK; Neurological Institute (R.N.A.), Tel Aviv Sourasky Medical Center, Israel; Department of Neurology (R.N.A.), Columbia University Irving Medical Center, New York, NY; Department of Neurology (M.J.B.), Virginia Commonwealth University, Richmond, VA; Department of Neurology (L.C.), University of Pittsburgh, PA; The Michael J. Fox Foundation for Parkinson's Research (J.L.E.), New York, NY; James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders (A.J.E.), Department of Neurology, University of Cincinnati; Cleveland Clinic (J.B.L.), Neurological Institute, Lou Ruvo Center for Brain Health, OH; Department of Neuroscience (I.L.), University of California San Diego; Parkinson's Disease Research, Education and Clinical Center (PADRECC) (J.M., D.W.), Crescenz Veteran's Affairs Medical Center, Philadelphia, PA; Department of Neurology (I.H.R.), University of Rochester, NY; Department of Neurology (L.R.), Johns Hopkins University, Baltimore, MD; and Department of Neurology (T.S.), Northwestern University, Chicago, IL; Departments of Neurology and Psychiatry and Behavioral Sciences (M.K.Y.), Baylor College of Medicine, Houston, TX.
帕金森病 (PD) 中的痴呆症似乎不那么常见,并且比以前认为的晚发. 新的研究表明PD患者的长期痴呆风险较低,来自大型前性研究.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
背景情况:
- 以前的研究表明,痴呆症影响高达80%的帕金森病 (PD) 患者.
- 这些早期的研究往往具有较小的样本规模和方法上的限制.
- 目前对PD中长期痴呆风险的理解需要进行更新的调查.
研究的目的:
- 确定患有帕金森病的个体中痴呆症的长期风险.
- 用大规模,正在进行的,前性,观察性研究的数据重新评估痴呆症患病率.
- 为了比较不同队列和诊断标准的痴呆症发病率.
主要方法:
- 利用了来自帕金森病进展标记计划 (PPMI) 和宾夕法尼亚大学PD队列的数据.
- 为PPMI招募了de novo,未经治疗的PD参与者和宾夕法尼亚州的一个方便队列.
- 在使用认知评估和专家共识的情况下,对痴呆症诊断的时间进行了间隔审查的生存分析.
主要成果:
- 在PPMI队列中,10年痴呆症的概率在9%至15%之间.
- 宾夕法尼亚大学的队列显示,痴呆症的中位时间为15年,其中47%被诊断为痴呆症.
- 据估计,10年后痴呆症的概率为27%,在宾夕法尼亚大学队列中,在15年后升至50%,在20年后升至74%.
结论:
- 研究结果表明,帕金森病的痴呆症发生的频率低于以前报告的频率.
- 在PD中痴呆可能在疾病的晚期发展.
- 结果挑战了以前的估计,并强调需要更新关于PD痴呆风险的研究.
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