复发性/耐药性多发性骨髓瘤的现实世界治疗模式和结果 (之前的1-3行):Flatiron数据库
Binod Dhakal1, Hermann Einsele2, Jordan M Schecter3
1Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.
Blood advances
|August 7, 2024
概括
用早期治疗线治疗的勒纳利多米德耐药多发性骨髓瘤 (MM) 患者面临着糟糕的结果和疾病的快速进展. 这凸显了迫切需要新的治疗方法来改善患者在患者因消耗而丧生之前的生存率.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床研究 临床研究
背景情况:
- 在多发性骨髓瘤 (MM) 中早期使用莱纳利多米德增加了莱纳利多米德耐药MM患者的数量.
- 在早期治疗环境中,对莱纳利多米德耐药MM患者的结局没有很好的描述.
研究的目的:
- 为了描述治疗模式,生存结果,预后变量和蛋白质酶抑制剂暴露,利那利多米德耐药MM的患者的衰退率.
- 评估患者治疗前1至3种疗法 (LOT) 的结果.
主要方法:
- 从Flatiron健康数据库 (2016年1月至2022年4月) 追溯分析了1455名勒纳利多米德耐药MM患者.
- 包括的患者先前接受了1到3次LOT,并暴露于蛋白酶体抑制剂.
- 分析治疗模式,现实世界无进展生存率 (RW-PFS),总生存率 (OS) 和累积消耗率.
主要成果:
- 最常见的后续治疗是三重组合 (41.6%),达拉图穆马布/波马利多米德/德克萨米他是最常见的治疗方案 (13.2%).
- 中位数RW-PFS为6.5个月,中位数OS为44.4个月.
- 国际分期系统III阶段,ECOG性能状态为1,低血红蛋白,高风险细胞遗传学和抗CD38抗体折射性与更糟糕的结果有关.
- 从LOT 2到5的累积消耗率在加入时具有1个先前LOT的患者中为85%.
结论:
- 患者与勒纳利多米德耐药MM接受1-3之前LOT表现出糟糕的结果和快速的疾病进展.
- 在疾病的早期发展过程中,急需更有效的治疗方法.
- 早期干预至关重要,以防止患者的消耗,并提高这一群体的长期存活率.
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