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骨和关节软骨的变化在肉肉与大腿骨头缩

Hongfan Ge¹, Yaling Yu¹, Yanyan Zhang¹

¹Department of Clinical Sciences, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, 210095, China.

Poultry science

|August 7, 2024

概括

肉的骨头亡 (FHN) 涉及骨质的下降和显著的软骨损伤,影响家禽的福利. 本研究详细介绍了与FHN相关的骨和软骨结构和功能的逐渐变化.

科学领域:

禽畜科学禽畜科学禽畜科学
兽医病理学兽医病理学
生物机械工程生物机械工程

背景情况:

骨头亡 (FHN) 是密集肉养殖中普遍存在的腿部疾病,对动物福利产生负面影响.
关节的异常机械应力是FHN发展的关键风险因素.
关节软骨在关节缓冲和滑中发挥着至关重要的作用,使其完整性至关重要.

研究的目的:

通过评估关节,骨和软骨的特征来研究 brojlers 中FHN 的进展.
评估FHN对关节软骨机械性能和结构完整性的影响.
识别与FHN相关的软骨中的细胞和细胞外基质变化.

主要方法:

使用计算机断层扫描 (CT),原子力显微镜 (AFM) 和传输电子显微镜 (TEM) 来分析肉的关节.
与对照组比较了患有FHN (大腿骨头分离和大腿骨头分离与生长板撕裂) 的 brojler.
评估了骨机械特性,软骨形态,表面摩擦,模量,刚度和细胞外矩阵组成.

主要成果:

患有FHN的肉表现出骨机械性能降低,关节空间狭窄,股骨头结构加厚.
在受FHN影响的肉中观察到异常的软骨形态,包括增加厚度和表面粗度.
软骨表现出增加的摩擦,降低度,状细胞损伤 (超微损伤,线粒体问题,氧化应激) 和ECM降解 (降低原蛋白和蛋白质甘氨酸含量,改变原蛋白结构).

结论:

FHN的特点是股骨头骨质量逐渐下降.
关节软骨的多方面的损伤,包括结构和功能障碍,与肉的FHN严重程度密切相关.
这些发现突显了软骨完整性在FHN病变发生过程中的关键作用,并表明了干预的潜在目标.

关键词:

brojler 肉肉是一个软骨软骨软骨是一种细胞外矩阵是细胞外矩阵.腿部头部亡的死亡.

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