沿着上升体感路径对振动刺激的神经编码的转换
Kuo-Sheng Lee1, Alastair J Loutit2, Dominica de Thomas Wagner2
1Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland; Institute of Biomedical Sciences, Neuroscience Program of Academia Sinica, Academia Sinica, Taipei, Taiwan.
Neuron
|August 7, 2024
概括
泰拉木斯将来自神经系统的快速振动信号转化为不同的代码. 泰拉马斯中的特定神经元提高频率检测,改变传感处理的时间.
科学领域:
- 神经科学是一个神经科学.
- 身体的感觉 (somatosensation) 是一种体内感觉.
- 感官编码 感官编码
背景情况:
- 哺乳动物机械敏感的接器精确地编码振动时间.
- 将时间振动代码转换为速率代码的神经通路和机制尚不清楚.
研究的目的:
- 为了研究时间振动代码沿体感路径转化为速率代码的变化.
- 为了确定参与这种感官编码转换的特定脑区和神经元群体.
主要方法:
- 电生理学记录在老鼠沿着上升的体感路径.
- 在不同的神经阶段探测振动刺激编码.
- 在大脑干中进行频率特定的微刺激.
主要成果:
- 时间到速率编码的主要转换发生在 thalamus.
- 乳头网状核中的帕尔瓦胺阳性内部神经元提高频率选择性,并破坏尖峰时间.
- 大脑干微刺激诱导了体感皮质的频率选择性,支持小鼠的学习.
结论:
- 泰拉马斯对于将时间振动信息转换为速率代码至关重要.
- thalamic电路,包括特定的内部神经元,调节感官处理.
- 这些发现可能会为针对体感路径的神经假肢的仿生策略提供信息.
相关概念视频
Somatosensation
36.5K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.5K
Overview of Somatic Sensory Pathways
4.3K
Somatic sensory or somatosensory pathways refer to the neural pathways that carry information related to touch, pressure, pain, temperature, and proprioception from the skin, muscles, tendons, and joints to the brain. These pathways involve several stages of processing and integration of sensory information.
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
The somatosensory system is divided into three main pathways: the dorsal (or posterior) column-medial lemniscus, spinothalamic (or anterolateral), and spinocerebellar pathways.
The dorsal...
4.3K
Sensory Perception: Organization of the Somatosensory System
2.9K
The somatosensory system is the central and peripheral nervous system component that senses and processes touch, pressure, pain, temperature, and body position or proprioception. The process of sensation takes place at three levels:
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
The receptor level:
The receptor level is the first stage of sensation. It involves the detection of a stimulus by specialized sensory receptors. The stimulus must arrive within the receptor's receptive field. Next, the receptor converts the energy of the...
2.9K
Major Somatic Sensory Pathways
931
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
931
Spinal Cord: Information Processing
1.2K
The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
1.2K
Somatosensory, Motor, and Association Cortex
455
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
455


