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Updated: Aug 9, 2026

Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation
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Published on: November 17, 2017

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在体内,SYNGAP1缺陷在异种移植的人类皮质神经元中破坏了突触新生

Ben Vermaercke1, Ryohei Iwata1, Keimpe Wierda2

  • 1VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; KU Leuven, Department of Neurosciences & Leuven Brain Institute, 3000 Leuven, Belgium.

Neuron
|August 7, 2024
PubMed
概括

人类大脑发育,或neoteny,对于认知至关重要. 这项研究表明,SYNGAP1缺乏会破坏这一过程,加速神经元成熟,影响智力障碍 (ID) 和自闭症谱系障碍 (ASD).

关键词:
在 SYNGAP1 里面,你会发现一个人.自闭症谱系障碍 自闭症谱系障碍大脑皮层 大脑皮层进化 演化 演化 演化 演化 演化 演化 演化人类大脑发育 人类大脑发育尼奥特尼尼尼尼尼尼尼尼尼尼尼尼神经发育疾病是神经发育疾病.

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Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders05:00

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