额叶皮层的不同基线功能模式在肌缩性侧面硬化症患者与皮层脊髓道高强度
Qianwen Li1, Wenjia Zhu2, Xinmei Wen2
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45, Changchun Street, Xicheng District, Beijing 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, No.45, Changchun Street, Xicheng District, Beijing 100053, China.
与CST-患者相比,肌缩侧面硬化症 (ALS) 皮质脊髓道高强度 (CST+) 患者表现出明显的前脑活动和连接模式,这表明存在潜在的补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
- 在近一半的ALS患者中,观察到皮层脊柱管 (CST) 过强度 (CST+).
- 在CST+和CST-ALS患者之间,大脑功能差异尚不清楚.
研究的目的:
- 调查ALS患者与没有CST强度过高之间大脑功能活动和连接模式的差异.
- 探索这些功能模式与ALS临床措施之间的关系.
主要方法:
- 从19名ALS CST+患者,41名ALS CST-患者和37名健康对照 (HC) 获得了休息状态功能性MRI (fMRI) 扫描.
- 使用低频波动幅度 (ALFF) 评估局部大脑活动.
- 使用基于网络的统计 (NBS) 分析了大脑连接模式.
主要成果:
- 健康对照组 (HC) 与ALS CST-和CST+患者相比,在上额头 (SFG) 和下额头 (OIFG) 中的ALFF较高.
- 一个额头网络包括SFG,OIFG,轨道额头,中间环状皮质和基底,显示出HC>ALS CST+>ALS CST-在功能连接中的模式.
- 在ALS CST-患者中,OIFG ALFF与ALSFRS-R相关,额头网络连接与疾病持续时间趋势;在ALS CST+患者中,这些相关性不存在.
结论:
- 患有CST超强度的ALS患者表现出前脑区域的基线功能活动和连接性发生变化.
- 在ALS CST+患者中,这些独特的模式可能代表了一个功能补偿机制.
- 这些发现突出了基于CST状态的ALS神经组织和补偿策略的潜在差异.
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