作为对和脂肪酸替换不和脂肪酸的反应,LDL胆固醇的变化:一种非随机的,连续的饮食干预;阅读,帝国,萨里,和脂肪胆固醇干预 ("RISSCI"-1) 研究
Athanasios Koutsos1, Bruce A Griffin2, Rona Antoni2
1Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, Institute for Food, Nutrition and Health, and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, United Kingdom.
用不和脂肪酸 (UFA) 取代食中的和脂肪酸 (SFAs) 有效地降低了LDL胆固醇. 然而,LDL胆固醇反应的显著个体变化被观察到,需要进一步研究个性化饮食策略的潜在决定因素.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 代谢研究研究 代谢研究
背景情况:
- 血清低密度脂蛋白 (LDL) 胆固醇对饮食脂肪变化的反应在个体之间存在显著差异.
- 和脂肪酸 (SFAs) 和不和脂肪酸 (UFA) 对心血管疾病 (CVD) 风险因素有不同的影响.
研究的目的:
- 评估英国饮食指南的有效性,即用UFA取代SFAs,降低LDL胆固醇和其他心血管疾病风险标志物.
- 确定导致LDL胆固醇对饮食脂肪修改反应变化的因素.
主要方法:
- 一项受控的饮食干预研究,涉及109名健康男性.
- 参与者每人4周食用高含SFAs的饮食,然后高含UFA (异能交换) 的饮食.
- 测量包括血清脂质,心血管疾病风险标志物和外周血液单核细胞 (PBMC) 基因表达.
主要成果:
- 转换为低SFA/高UFA饮食显著降低了LDL胆固醇,HDL胆固醇,总胆固醇和阿波利波蛋白B.
- 胆固醇吸收和合成的生物标志物增加,以及LDL受体mRNA的表达.
- 观察到LDL胆固醇反应的范围广泛,基线LDL和SFA降低解释了部分变化.
结论:
- 英国关于用UFA取代SFA的饮食指南在降低整体LDL胆固醇方面是有效的.
- 在LDL胆固醇反应中存在显著的个体间变异性,强调需要确定特定的决定因素.
- 进一步的研究对于个性化和提高食脂质指南的有效性至关重要.
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