在自闭症谱系障碍的PTEN删除模型中,听觉处理中的发育轨迹和性别差异
Katilynne Croom1, Jeffrey A Rumschlag2, Gemma Molinaro3
1Graduate Neuroscience Program, University of California, Riverside, United States of America.
Neurobiology of disease
|August 7, 2024
概括
这项研究表明,患有Pten基因删除的小鼠,这是自闭症谱系障碍 (ASD) 的模型,表现出显著的听觉处理缺陷. 这些时间处理和过敏度的缺陷存在于早期,随着年龄的增长而恶化,影响语言发展.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展生物学 发展生物学
背景情况:
- 自闭症谱系障碍 (ASD) 的特点是感官缺陷和语言障碍,与遗传风险因素的联系不清楚.
- 在ASD中早期的感官缺陷可能会导致青春期和成年期更严重的症状.
- 在ASD诊断和表现中存在性别偏见,但基本机制尚不清楚.
研究的目的:
- 调查ASD的Pten-deletion小鼠模型中的听觉灵敏度和时间处理中的发育,基因型依赖和性别依赖的差异.
- 在ASD的背景下,探索听觉时间处理缺陷在语言发展中的作用.
- 在这个ASD小鼠模型中检查感官处理异常的性别差异.
主要方法:
- 从发育和成年Nse-cre PTEN条件淘汰 (cKO) 小鼠的前额皮质 (FC) 和听觉皮质 (AC) 记录了外周电脑电图 (EEG).
- 静止EEG光谱功率,听觉事件相关潜力 (ERP) 和使用差距噪声ASSR范式的时间处理被量化.
- 试验间阶段聚类 (ITPC) 用于测量皮质对快速声音间隙的影响,评估时间处理.
主要成果:
- PTEN cKO小鼠的静止EEG功率发生变化,β功率增加,AC和FC中高频振荡减少.
- 雄性和雌性cKO小鼠都表现出减少的ITPC,表明时间处理缺陷,在成年人中变得更加明显.
- 与雄性相比,雌性cKO小鼠表现出更高的过敏度,由较大的N1和P2幅度证明.
结论:
- 皮特删除小鼠模型显示显著的听觉处理缺陷,包括异常的时间处理和过敏,从一个早期的发育阶段.
- 在PTEN cKO模型中,这些感官处理异常可能是自闭症谱系障碍中观察到的语言发展问题的基础.
- 这些发现强调了在研究与自闭症相关的感官处理缺陷时考虑性别差异的重要性.
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