益生菌水平与认知功能在患有严重精神障碍的女性患者之间的关联
Yichong Xu1,2, Shun Yao1,2, Zhiying Yang1,2
1Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Psychiatry investigation
|August 7, 2024
概括
血清素水平升高与患有严重精神障碍 (SMD) 的女性患者的认知障碍有关. 监测益乳素对于预防这一群体的认知衰退至关重要.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 认知障碍是严重精神障碍 (SMD) 的核心特征.
- 超益乳血症 (高益乳水平) 可能会对SMD患者的认知功能产生负面影响.
研究的目的:
- 调查SMD的女性患者血清前素水平和认知功能之间的关系.
主要方法:
- 一项涉及294名女性SMD患者和195名健康对照 (14-15岁) 的研究.
- 使用可重复电池评估神经心理状态 (RBANS) 评估认知功能.
- 测量血清益乳素水平;统计分析包括描述性,比较性和线性回归模型.
主要成果:
- 与对照组相比,SMD患者的益生菌水平较高,RBANS得分较低.
- 在SMD患者中,发现了益生菌水平和认知功能 (总得分,注意力,延迟记忆) 之间的负相关性.
- 这种反向关系甚至在不服用影响益生菌素的药物的患者中也存在.
结论:
- 升高的益生菌水平与女性SMD患者的认知障碍有显著的关联.
- 监测益乳素水平对于预防这种群体的认知恶化很重要.
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