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自主造血干细胞移植用于儿科自身免疫神经系统疾病

Kirill Kirgizov¹, Joachim Burman², John A Snowden³

¹Nikolay Blokhin National Medical Research Center of Oncology, Moscow, Russia.

Handbook of clinical neurology

|August 7, 2024

概括

自主造血干细胞移植 (aHSCT) 对患有重症多发性硬化症 (MS),光学神经炎症 (NMO) 和慢性炎症性脱髓化多发性神经病变 (CIDP) 的儿科患者显示出希望. 该程序旨在重置免疫系统,在精心挑选的病例中提供长时间的疾病控制.

科学领域:

神经学神经学
免疫学免疫学免疫学
血液学血液学血液学

背景情况:

像MS,NMO和CIDP这样的儿科炎症性脱髓化疾病可能是严重的,并且对标准治疗具有耐药性.
自主造血干细胞移植 (aHSCT) 是针对某些自身免疫性疾病的一种成熟疗法.

研究的目的:

审查aHSCT在被诊断为MS,NMO和CIDP的儿科患者的疗效和安全性.
概述HSCT在这个特定人群中的程序步骤和考虑因素.

主要方法:

摘要描述aHSCT是一个多步骤的程序,涉及患者选择,移植前准备,干细胞调动,淋巴切除条件,干细胞输液和移植后监测.
重点是免疫系统重置和耐受性诱导的机制.

主要成果:

现有证据表明,aHSCT对于儿科多发性硬化症是安全的,可以实现长时间的疾病控制.
该程序通过消除自身反应细胞和再生免疫系统来恢复自我耐受性来起作用.

结论:

对于经过精心挑选的患有严重或耐药性MS,NMO和CIDP的儿科患者来说,aHSCT是一种可行的治疗选择.
建议采取谨慎的方法,在多学科环境中考虑较少有毒的替代方案后,为严重病例保留HSCT.

关键词:

自免疫性疾病自免疫性疾病孩子孩子孩子孩子造血干细胞移植造血干细胞移植多发性硬化症是多发性硬化症.

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