在EBMT-ADWP和CIBMTR
Raffaella Greco1, Manuela Badoglio2, Myriam Labopin2
1Hematology and Bone Marrow Transplant Unit, IRCCS San Raffaele Hospital, Milan, Italy; Universitá Vita-Salute San Raffaele, Milan, Italy.
Handbook of clinical neurology
|August 7, 2024
概括
造血干细胞移植 (HSCT) 为严重的神经系统自身免疫性疾病 (AD) 提供了深刻的免疫重置. 像EBMT和CIBMTR这样的注册表跟踪HSCT,用于诸如多发性硬化症 (MS) 等疾病.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 造血干细胞移植 (HSCT) 已成为严重的神经系统自身免疫性疾病 (ADs) 的关键治疗方法,通过消除疾病记忆和重置免疫系统.
- 针对AD的HSCT领域目前处于一个动态的发展阶段,正在进行大量数据收集工作.
- 主要的移植注册机构,包括欧洲血液和骨髓移植学会 (EBMT) 和国际血液和骨髓移植研究中心 (CIBMTR),对于跟踪这些进展至关重要.
研究的目的:
- 提供EBMT和CIBMTR关于神经系统自身免疫疾病的HSCT注册表的概述.
- 介绍与神经学ADs的HSCT相关的当前状态和出版输出.
- 突出HSCT在管理多发性硬化症 (MS) 等疾病中的作用.
主要方法:
- 来自EBMT注册表的数据分析,EBMT注册表是全球最大的AD中HSCT数据库,报告了超过3700次移植.
- 审查CIBMTR的数据,专注于美洲的神经疾病的自主HSCT.
- 对神经系统疾病的移植趋势和出版成果的检查.
主要成果:
- 该EBMT注册表包括超过3700个AD的移植,多发性硬化症 (MS) 占这些手术的约50%.
- 在美洲,针对神经疾病进行了1030次自主HSCT,MS占这些诊断的96%.
- 虽然美国MS的HSCT活动相对较低,但近年来已经出现了增加,墨西哥报告了这些移植的急剧增加.
结论:
- HSCT是治疗多发性硬化和其他神经系统自身免疫性疾病的综合和标准治疗方法.
- 来自EBMT和CIBMTR的注册表数据对于了解这些条件的HSCT不断变化的格局至关重要.
- 持续的监测和研究对于优化神经性ADS患者的HSCT协议和结果至关重要.
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