艾滋病毒感染者的癌症
Thomas A Odeny1, Valeria Fink2, Mazvita Muchengeti3
1Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave., CB 8056, St. Louis, MO 63110-1093, USA.
Infectious disease clinics of North America
|August 7, 2024
概括
艾滋病毒感染者因感染和炎症而面临更高的癌症风险. 有效的查,预防和治疗策略对于管理这种人群中的癌症至关重要.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 人类免疫缺陷病毒 (HIV) 感染与癌症风险增加有关.
- 致癌性感染,慢性炎症和行为因素有助于增加这种风险.
- 艾滋病毒感染者 (PWH) 需要量身定制的癌症管理方法.
研究的目的:
- 审查艾滋病毒和癌症的全球交叉点.
- 讨论PWH癌症查,预防和治疗的当前建议.
- 突出新型疗法和包容性临床试验的需要.
主要方法:
- 关于艾滋病毒和癌症研究的综合文献综述.
- 对PWH癌症管理当前指南的分析.
- 讨论具体的干预措施和治疗考虑.
主要成果:
- 艾滋病毒阳性个体具有复杂的因子相互作用,增加癌症风险.
- 关键干预措施包括疫苗接种,降低风险,早期艾滋病毒诊断和治疗以及向癌症查.
- 多方面的治疗策略,支持性护理和药物相互作用的管理对于PWH至关重要.
结论:
- 在PWH治疗癌症需要多学科的方法.
- 新疗法和包容性临床试验对于未来的进步至关重要.
- 持续的合作努力至关重要,以减少PWH之间的癌症负担.
相关概念视频
Sexually Transmitted Infections
292
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
292
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K
Retrovirus Life Cycles
45.8K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.8K
Psychoneuroimmunology: Diabetes and Cancer
27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K


