癌症中的挥发性有机化合物和呼气检测技术
Xinyuan Zhou1, Manqing Qi1, Mingqi Tang1
1Life and Health Intelligent Research Institute, Tianjin University of Technology, Tianjin, P.R. China.
Advances in clinical chemistry
|August 7, 2024
概括
在呼吸中检测挥发性有机化合物 (VOC) 对早期癌症查具有前途. 生物标志物识别和专用设备的挑战阻碍了临床使用,但研究正在探索新的检测技术.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 分析化学 分析化学
背景情况:
- 使用挥发性有机化合物 (VOCs) 进行呼吸分析是早期癌症检测的有希望的非侵入性方法.
- 尽管有科学兴趣,但由于生物标志物识别的挑战和专门设备的要求,临床采用是有限的.
研究的目的:
- 检查用于癌症查的呼气中检测气体生物标志物的研究策略.
- 审查检测原则,临床应用和与癌症检测中的VOC分析相关的挑战.
主要方法:
- 代谢学方法分析癌症患者呼吸中的气体生物标志物和癌细胞代谢物.
- 对用于呼吸分析的大型分析仪器和小型传感器技术的审查.
- 探索与癌症中的VOC相关的代谢途径.
主要成果:
- 确定了七种不同类型癌症的气体生物标志物.
- 突出了大型分析仪器和微型传感器技术的进步.
- 讨论了包括临床整合,样本提取,检测灵敏度和小型化在内的挑战.
结论:
- 呼吸中的挥发性有机化合物 (VOC) 对早期癌症检测具有重大潜力.
- 克服生物标志物特异性的挑战和开发敏感,特定的检测设备对于临床翻译至关重要.
- 继续在代谢学和传感器技术方面的研究对于推进基于呼吸的癌症诊断至关重要.
相关概念视频
Serum Laboratory Studies, Stool Test, Breath Test
325
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
325
Gas Chromatography: Types of Detectors-II
349
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
349
Gas Chromatography: Types of Detectors-I
390
There are different types of detectors used in gas chromatography, each with its own specific properties that make it suitable for detecting certain types of analytes. The most commonly used detectors in GC are thermal conductivity detector (TCD), flame ionization detector (FID), and electron capture detector (ECD).
TCD is the earliest and most widely used detector that operates by measuring the changes in the thermal conductivity of the carrier gas. When a sample compound enters the detector,...
TCD is the earliest and most widely used detector that operates by measuring the changes in the thermal conductivity of the carrier gas. When a sample compound enters the detector,...
390
Assessment of Diffusion and Perfusion
963
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
963
Gas Chromatography: Overview of Detectors
472
Detectors in gas chromatography (GC) help identify and quantify the components of a mixture by translating chemical properties into measurable signals, which are displayed on a chromatogram. Detectors can be categorized into two main types: destructive and non-destructive.
A non-destructive detector allows a sample to be analyzed without altering or consuming it, meaning the sample can be collected after detection for further analysis. Examples include thermal conductivity detectors and...
A non-destructive detector allows a sample to be analyzed without altering or consuming it, meaning the sample can be collected after detection for further analysis. Examples include thermal conductivity detectors and...
472
High-Performance Liquid Chromatography: Types of Detectors
515
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
515


