在患有自身免疫性胃炎的患者中内镜性胃息肉的发生和特征 (AGAPE研究):一个多中心横截面研究
Sara Massironi1, Camilla Gallo1, Edith Lahner2
1Division of Gastroenterology IRCCS San Gerardo dei Tintori Monza, MB, Italy and Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
自身免疫性胃炎 (AIG) 显著增加胃聚合物的风险,包括癌症和神经内分泌瘤. 定期内镜监测对于AIG患者的早期检测和治疗至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 自身免疫性胃炎 (AIG) 的特征是低水,导致胃素水平升高.
- 这些高的胃素水平可以刺激胃粘膜的增殖.
研究的目的:
- 确定患有自身免疫性胃炎 (AIG) 的患者胃多的发生率和特征.
- 在大型队列中分析相关的风险因素和病变类型.
主要方法:
- 这是一项多中心,横截面的研究,涉及612名来自意大利六个高等医疗中心的AIG患者.
- 从2000年1月到2023年6月,数据收集包括人口统计,临床病史,生化资料和内镜/病原学发现.
主要成果:
- 36.3%的AIG患者患有胃聚体,222人受影响.
- 常见的非内分泌多包括炎症性 (70.5%) 和腺瘤性 (13.6%) 类型. 6.1%的人是腺癌.
- 在108名患者中发现了胃神经内分泌瘤 (gNENs). 年龄较大和高的胃素/染色素A水平与多发生相关.
结论:
- 胃聚体,包括gNEN和腺癌,在AIG患者中很常见.
- 积极的内镜监测和组织病理学检查对于管理AIG相关的胃病变至关重要.
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