酸纳米颗粒增加了口腔上皮细胞对阿西克洛维尔的吸收
Priti P Rath1, Hardik Makkar2, Shruti Vidhawan Agarwalla1
1Faculty of Dentistry, National University of Singapore, Singapore.
牛油酸纳米颗粒增强了口腔疹治疗的阿西克洛维尔输送. 这些纳米颗粒改善了药物吸收到口腔上皮细胞中,显示持续释放和细胞吸收增加.
科学领域:
- 纳米技术 纳米技术
- 药品制造 药品制造 药品制造
- 口腔医学是指口腔医学.
背景情况:
- 乙克洛维尔 (ACY) 是口腔疹的关键抗病毒药物,但具有较差的溶解性和生物可用性.
- 酸 (SA) 是一种脂性物质,具有药物制剂的潜力.
- 在口腔上皮细胞中增强ACY细胞吸收对于有效治疗至关重要.
研究的目的:
- 为了表征酸 (SA) 纳米颗粒,以改善阿西克洛维尔 (ACY) 输送.
- 评估基于SA的纳米颗粒的稳定性和药物动力学特征.
- 评估SA纳米颗粒对口腔上皮细胞ACY细胞吸收的影响.
主要方法:
- 制造和优化了含有ACY的SA固体脂质纳米粒子 (SLN).
- 在各种储存条件下 (4°C和37°C) 评估了粒子稳定性.
- 研究了药理动力学,细胞毒性,体外透性和基因表达调制.
主要成果:
- SA纳米颗粒显示持续的ACY释放与最初的爆发.
- 在储存45天后,在120分钟内观察到高药物释放率 (>90%),即使在储存45天后.
- 用SA纳米颗粒治疗的细胞显示细胞内ACY含量显著增加,TJP-1,OCLN和ECAD的表达增加.
结论:
- SA纳米颗粒有效地维持阿西克洛维尔的输送,并增强其吸收到口腔上皮细胞中.
- 开发的SA纳米颗粒有望提高ACY在治疗口腔疹 (HSV-1) 的疗效.
- 这种配方策略代表了口腔感染抗病毒药物输送的重大进步.
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