甲基普雷迪尼索隆诱导的早晨淋巴细胞症:在患有免疫媒介炎症疾病的患者中进行的一项前性研究
Camille Beniada1, Bruno Couturier1, Florence Reye2
1Department of Internal Medicine, hôpital Erasme, université libre de Bruxelles, Brussels, Belgium.
概括
甲基prednisolone (mPDN) 在患有炎症疾病的患者中可以引起早期淋巴细胞瘤,而不是淋巴缺血. 普罗巴诺洛尔没有影响甲基前尼索隆诱导的淋巴细胞计数增加.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 葡萄糖皮质类药物通常会导致淋巴缺血,但有事报道淋巴细胞症.
- 甲基prednisolone (mPDN) 诱导的淋巴细胞瘤的确切时间和程度需要进行前性调查.
- 与此同时服用的药物,如普拉诺洛尔,对调节这种反应的作用尚不清楚.
研究的目的:
- 为了前性地确定甲基prednisolone (mPDN) 诱导的淋巴细胞瘤的时间和程度.
- 为了研究在mPDN治疗期间同时服用普拉诺洛尔对淋巴细胞计数 (Ly) 的影响.
主要方法:
- 在20名患有免疫媒介炎症疾病 (IMID) 的患者中,在开始mPDN之前和24-72小时后测量了淋巴细胞计数.
- 患有Ly增加的患者随机分配给与mPDN一起接受普罗布拉诺洛尔或安慰剂,并重新评估Ly.
- 淋巴细胞亚群和mPDN血水平被分析为子集.
主要成果:
- 18/20患者在开始mPDN后48-72小时内观察到Ly的73.4%的增加.
- 7名患者发生了淋巴细胞 (≥4000/μL),4名患者发生了淋巴细胞 (≥5000/μL).
- 普罗普拉诺洛尔的使用并没有显著改变淋巴细胞计数 (p=0.570).
结论:
- 在mPDN治疗期间的早晨淋巴细胞瘤在服用后的头几天内出现.
- 这些发现不支持增加上腺素度作为mPDN诱导的淋巴细胞瘤的原因.
- 确定这种意想不到的淋巴细胞瘤病因可能会防止不必要的临床调查.
关键词:
上腺激素的音调.贝塔阻塞剂 贝塔阻塞剂贝塔阻断剂是一种β阻断剂.葡萄糖皮质类药物是什么葡萄糖皮质类药物淋巴细胞瘤症 淋巴细胞瘤症甲基普雷迪尼索隆 (Methylprednisolone) 是一种可以甲基普雷迪尼索隆 (Methylprednisolone) 是一种药物.这是一个非常有活力的Tonos adrénergique.更多相关视频
07:04Immunostimulatory Agent Evaluation: Lymphoid Tissue Extraction and Injection Route-Dependent Dendritic Cell Activation
Published on: September 16, 2018
10.1K
12:36Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
Published on: June 26, 2018
9.4K
相关概念视频
Disorders of Leukocytes
923
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
923
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
149
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
149
T Cell Types and Functions
966
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
966
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
109
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
109
