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光激活的循环多甲微囊用于有效载荷交付.

Youngsu Shin1, Jared M Schwartz1, Anthony C Engler2

  • 1School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

ACS applied materials & interfaces
|August 7, 2024
PubMed
概括

研究人员使用循环多甲 (cPPA) 开发出可光触发的微囊. 这些微囊可以在暴露在紫外线下时按需释放石油有效载荷,提供了多功能可控释放技术.

关键词:
乳化 乳化 乳化 乳化转移稳定的聚合物.微囊 微囊是一种微囊.这是一个光酸发生器.这是一种可摄影触发的光触发器.聚甲二氧化的使用方法刺激-响应的刺激.过渡性聚合物过渡性聚合物

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科学领域:

  • 聚合物化学 聚合物化学
  • 材料科学 材料科学 材料科学
  • 纳米技术 纳米技术

背景情况:

  • 微囊对于控制释放的应用是必不可少的.
  • 开发响应刺激的材料对于先进的传递系统至关重要.
  • 光触发性脱聚合提供了精确的有效载荷释放机制.

研究的目的:

  • 制造和表征具有循环多甲 (cPPA) 的可光触发微,用于控制的有效载荷释放.
  • 研究不同光酸生成器 (PAG) 对释放动态的影响.
  • 评估共聚合物外的性能,以提高释放率.

主要方法:

  • 通过乳化来制造cPPA微囊.
  • 将光酸发生器 (PAG) 嵌入cPPA外中.
  • 使用紫外线辐射进行光激活,以诱导脱聚合和有效载荷释放.
  • 使用1H NMR光谱测量核心释放的量化.
  • 甲/甲共聚合物外的合成和表征.

主要成果:

  • 成功制造了带有cPPA外的统一球形微囊.
  • 光酸发生器 (BCSD和HNT) 实现了可光触发的脱聚合.
  • 基于HNT的微囊显示,在紫外线照射时,核心瞬间释放.
  • 对cPPA/HNT微囊的紫外线暴露导致66.5%的核心释放.
  • 甲/甲共聚合物外的释放速度更快 (82%在30年代).

结论:

  • 开发的可光触发的cPPA微囊提供了一个多功能平台,可按需释放疏水性有效载荷.
  • 选择PAG显著影响释放触发器和速度.
  • 共聚合物外提供了增强的释放动力学,扩大了应用潜力.
  • 这项技术对于需要精确和可控交付的应用具有前景.