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双向门德尔随机化,以探索肠道微生物群与男性生殖疾病之间的因果关系

Xiaofang Han¹, Hui Tian², Liu Yang²

¹Core Laboratory, Shanxi Provincial People's Hospital (Fifth Hospital of Shanxi Medical University), Taiyuan, China. hxfkgwy@163.com.

Scientific reports

|August 7, 2024

概括

肠道微生物与男性不孕症和异常精子有关. 这项研究使用了门德尔的随机化来证实8种肠道细菌因果关系影响男性生殖健康,为微生物治疗铺平了道路.

科学领域:

微生物学微生物学
生殖生物学生殖生物学
遗传学是一个遗传学.

背景情况:

男性生殖系统障碍,包括不孕不育和精子异常,是严重的健康问题.
肠道微生物群在这些条件中的确切作用在很大程度上仍未确定.

研究的目的:

调查肠道微生物组成和男性生殖系统疾病之间的潜在因果关系.
识别与男性不孕症和异常精子相关的特定肠道细菌.

主要方法:

采用孟德尔随机化 (MR) 分析,包括MR-Egger,加权中位数和逆差权重方法.
通过各种指标验证了MR发现,反向因果分析 (双向MR,施泰格过) 和生物功能丰富分析.

主要成果:

确定了8种与男性不孕症因果相关的肠道微生物群.
发现Eubacterium oxidoreducens群与男性不孕症风险增加有关,而Bacteroidaceae家族与男性生殖系统疾病负面相关.
八种肠道菌群与异常的精子有关,Streptococcaceae家族与高风险相关,Porphyromonadaceae家族与低风险相关.

结论:

在特定的肠道细菌和男性生殖健康结果之间建立了因果关系.
肠道微生物组是针对男性不孕症和相关疾病的新型治疗策略的潜在目标.

关键词:

在GWAS中,GWAS就是GWAS.基因组广泛的关联研究研究.我们的肠道微生物群.男人生殖系统疾病男人生殖系统疾病门德尔的随机化精子精子精子

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