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综合性转录组分析揭示了EGFR突变肺癌中T细胞反应受损的基础分子事件

Yu Zhao1, Gu Tang1, Jun Li1

  • 1Department of Immunology, Medical School of Nantong University, Nantong, Jiangsu, China.

Scientific reports
|August 7, 2024
PubMed
概括

肺腺癌中的表皮生长因子受体 (EGFR) 突变创造了一个免疫抑制瘤微环境. 这会通过降低T细胞相互作用和招募调节性T细胞来阻碍免疫治疗的反应.

关键词:
在 EGFR 基因突变.癌症免疫疗法癌症免疫疗法肺癌是一种肺癌.单细胞转录组是一个单细胞转录组.瘤微环境是一个微环境.

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