对Enterococcus faecalis与Enterococcus faecium血流感染的临床特征,诱导因素和结果:一个前性的多中心队列研究
Fenna Scharloo1,2, Francesco Cogliati Dezza3,2, Inmaculada López-Hernández2,4
1Faculty of Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
概括
菌和菌血流感染 (BSI) 有不同的易感因素和预后. 识别这些差异有助于早期诊断和治疗肠球菌BSI的决策.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 流行病学 流行病学
背景情况:
- 肠球菌血流感染 (BSI) 与高发病率和死亡率有关.
- 在Enterococcus faecalis和Enterococcus faecium感染之间存在明显的微生物学和临床特征.
研究的目的:
- 调查E. faecalis和E. faecium BSI的不同诱导因素.
- 探索与这些肠球菌BSI相关的预后因素.
主要方法:
- 对前性多中心PROBAC队列研究 (2016-2017年) 的后期分析.
- 包括患有E. faecalis或E. faecium BSI的患者.
- 后勤回归用于确定BSI发展和住院死亡率的预测因素.
主要成果:
- E. faecium BSI与之前的青素/碳烯使用有关,医院获得的BSI,以及胆汁源.
- E. faecalis BSI与充血性心力衰竭,脑血管疾病和尿路疾病有关.
- SOFA评分预测了两种物种的死亡率;查尔森并发症指数和年龄也预测了E. faecalis BSI的死亡率.
结论:
- 易患E. faecium和E. faecalis BSI的因素有很大的不同.
- 这些已识别的变量可以指导在经验性治疗中对特定肠球菌物种的怀疑.
- 结果为管理肠球菌BSI提供了有价值的预后信息.
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