评估和比较9个基于成长和发展的青春期时间的成长和发展指标
Ahmed Elhakeem1,2, Monika Frysz3,4, Ana Goncalves Soares3,5
1MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. a.elhakeem@bristol.ac.uk.
Communications medicine
|August 7, 2024
概括
青春期的时间指标各不相同,早期的迹象如乳腺发育和晚期的迹象如初潮. 儿童时代的身体组成会影响青春期的时间,影响终身健康.
科学领域:
- 人类的成长和发展是人类的成长和发展.
- 青春期研究 青春期研究
- 生命过程流行病学
背景情况:
- 青春期的时间是遗传的,并且在个体之间有很大的差异.
- 了解不同青春期计时指标之间的关系至关重要.
- 这些变化对长期健康结果有影响.
研究的目的:
- 量化比较9个不同的青春期计时指标.
- 分析这些指标之间的表型和遗传相关性.
- 调查青春期计时指标与青春期遗传风险评分 (GRS) 以及儿童身体组成之间的关系.
主要方法:
- 利用了来自8,500多名 (7-17岁) 个体的基于人口的队列的数据.
- 通过问卷收集数据,测量身高,体重和骨.
- 对比了9个基于生长和发育的青春期时间指标,分析了它们的发病年龄,相关性以及与GRS和身体组成的关系.
主要成果:
- 确定了早期指标 (例如,男性的阴毛,女性的乳腺发育) 和晚期指标 (例如,声音断裂,初潮).
- 在所有青春期计时指标中观察到显著的正面表型和遗传相关性.
- 发现初潮时的年龄和语音断裂GRS与其他青春期指标有积极的关联;更高的儿童脂肪和瘦肉质与早期青春期相关.
结论:
- 这项研究为测量青春期生长和发育时间提供了有价值的见解.
- 证明了各种青春期计时指标在终身健康研究中的有用性.
- 突出了遗传因素,身体组成和青春期的时间之间的复杂相互作用.
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