在常规CT扫描上探索骨密度分析,作为机会性骨质疏松症查工具
Nadia A du Fossé1, Willem Grootjans2, Ana Navas2
1Department of Intensive Care, Leiden University Medical Center, Leiden, The Netherlands.
Scientific reports
|August 7, 2024
概括
计算机断层扫描 (CT) 扫描可以选重症监护室 (ICU) 患者的低骨密度. 显著比例的COVID-19ICU患者显示骨密度下降,在长时间的ICU停留期间没有变化.
科学领域:
- 放射学 放射学是一门学科.
- 密集护理医学 密集护理医学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 骨密度下降是重症监护室 (ICU) 患者的一个担忧.
- 在重症患者中查骨质疏松症是具有挑战性的.
- 计算机断层扫描 (CT) 扫描通常在ICU中进行.
研究的目的:
- 评估基于CT的第12个胸椎 (Th12) 骨密度分析,作为ICU患者骨密度降低的查工具.
- 为了确定COVID-19患者入院ICU的低骨密度的患病率.
- 评估长时间ICU住院对骨密度的影响.
主要方法:
- 从38名COVID-19患者的118张CT扫描进行了回顾性分析,这些患者被送往ICU.
- 骨密度在Th12水平使用Hounsfield单位 (HU) 进行测量.
- 评估了观察者间的变异性和对比剂的使用效果.
主要成果:
- 观察者之间有良好的一致性 (类内相关系数[ICC]=0.93).
- 对比度增强稍微增加了骨密度测量 (+7.5 HU).
- 37%的患者表现出骨密度<140 HU,表明骨质疏松症.
- 在入院和随访扫描 (≥21天) 之间没有发现骨密度的显著差异.
结论:
- 基于脊椎CT的骨密度分析是一种可行的方法,用于查ICU患者的骨密度下降.
- 在研究的COVID-19ICU队列中发现了低骨密度的高患病率.
- 在这组患者中,长期的ICU停留并没有显著改变骨密度.
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