使用RESOLV与聚合物生产普拉佐辛化纳米颗粒,并优化工艺参数
Eslam Ansari1, Bizhan Honarvar2, Seyed Ali Sajadian3,4
1Chemical Engineering Department, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Scientific reports
|August 7, 2024
概括
超临界溶液迅速扩张成液体溶剂 (RESOLV) 成功产生了普拉佐辛化纳米粒子. 这种新的方法显著降低了颗粒大小和改变了结晶性,为制药纳米颗粒生产提供了一种新的方法.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 普拉佐辛化 (PRH) 是一种药物化合物,需要精确的颗粒大小控制才能有效地输送.
- 传统的纳米粒子生产方法可能很复杂,并且可能并不总是产生最佳结果.
研究的目的:
- 首次利用超临界溶液进入液溶剂的快速膨胀 (RESOLV) 技术,生产普拉佐辛化 (PRH) 的制药纳米颗粒.
- 为了优化 RESOLV 过程,使用 Taguchi 方法进行强大的实验设计.
- 为了研究压力,温度和喷嘴直径对PRH纳米粒子特性的影响.
主要方法:
- 使用RESOLV技术生成PRH纳米粒子.
- 塔古奇方法用于实验设计和优化.
- 颗粒大小从大约40μm减少到252-418nm.
- 福利埃变换红外光谱 (FTIR),动态光散射 (DLS),场发射扫描电子显微镜 (FESEM),X射线衍射 (XRD) 和差分扫描热量计 (DSC) 被用于表征.
主要成果:
- 在RESOLV过程中,成功地产生了PRH纳米粒子,其大小在252-418nm之间.
- 使用塔古奇方法确定了最佳的工艺条件.
- FTIR,DLS,FESEM和XRD证实了纳米粒子的形成和特性.
- DSC的分析表明,与原来的PRH相比,RESOLV生产的PRH的晶度较低.
结论:
- RESOLV技术是一种可行且有效的方法,用于生产Prazosin化的制药纳米颗粒.
- 该研究成功地优化了RESOLV过程参数用于纳米粒子生成.
- 描述的纳米粒子具有改变的结晶性,这可能会影响它们的制药性质.
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