三甘油-葡萄糖相关指数与一般人群中全因和因特定死亡率之间的关联:一个队列研究
Shan Li1, Li An2, Zhiqing Fu1
1Department of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China.
甘油三糖指数 (TyG) 和相关标志物预测一般人群的死亡风险. 较高的TyG指数值与所有原因,心血管和非心血管死亡率的增加有关.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 甘油三糖 (TyG) 指数是胰岛素抵抗和心脏代谢疾病的公认标志物.
- 它对死亡风险的预测价值需要在不同人群中进一步验证.
研究的目的:
- 调查TyG指数和相关指数与所有原因和特定原因死亡率之间的关联.
- 探索 TyG 相关指数在一般人群中的预测能力.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) (1999-2018) 的27,642名参与者的数据.
- 构建并分析了三个指数:TyG指数,TyG腰与身高比 (TyG-WHtR) 和TyG腰围 (TyG-WC).
- 使用加权的考克斯比例危险模型和受限制的立方线来评估死亡率关联.
主要成果:
- 所有三个与TyG相关的指数都显示,在增加的四分位数中,所有原因,心血管和非心血管死亡率逐渐增加.
- TyG指数的最高四分位数显示所有原因死亡率的危险比为1.26,心血管死亡率为1.38和非心血管死亡率为1.23.
- TyG-WHtR和TyG-WC也显示出与死亡率增加的显著关联,在所有指数中观察到J形关系.
结论:
- 与TyG相关的指数作为所有原因和特定原因死亡率的独立预测指标.
- 年轻人可能需要更密切的监测,而低LDL-C和他类药物的使用似乎有保护作用.
- 这些发现突显了基于TyG的标志物在风险分层中的临床实用性.
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